We cannot rule out that differences we observed in the CDA patient could be due to the genetic background but we do believe that the generation of an inducible KLF1-E325K activation iPSC line and its comparison with an inducible KLF1-WT iPSC line generated in the same genetic background strengthens the hypothesis that the differences observed in erythroid cell differentiation of the patient line is associated with the K325K mutation. Here, KLF1 is linked to congenital dyserythropoietic anemia.