Although the involvement of DLD in the constitutive pyruvate dehydrogenase complex (PDC) and α-ketoglutarate dehydrogenase complex (KGDC) has been identified as an important metabolic target in cancer (Kim et al., 2006; Semenza, 2010; Atlante et al., 2018), the role of DLD in the metabolism of tumor cells is less explored. Here, PDC is linked to cancer.