MYC and Burkitt lymphoma: To improve the accuracy of FISH in diagnosis of BL, two probe strategies were utilised, a tri-colour, dual fusion strategy for the t(8;14) and a break apart strategy for MYC. For the 16 specimens with a histological diagnosis of BL, positive results with the t(8;14) probe set were obtained for 13/16 (81%) in the ARL lab compared to 14/16 (87.5%) in the IU FISH lab.