CD274 and ovarian carcinoma: Since NLRC5’s primary function is to selectively activate MHC class 1 genes and other genes involved in the MHC class 1 antigen presentation pathway, the positive correlation between PD-L1 and NLRC5 suggests that PD-L1 upregulation and MHC class 1 downregulation are two mutually exclusive mechanisms of immune evasion used by ovarian cancer cells; meaning that when one of them is deployed, the other is repressed.