Besides, probiotics Lactobacillus reuteri GMNL-263, Bifidobacterium breve CECT7263 (BFM), Lactobacillus fermentum CECT5716 (LC40), and L. coryniformis CECT5711 (K8) plus L. gasseri CECT5714 (LC9) (1:1), prevent dysbiosis, endothelial dysfunction, endotoxemia, and high blood pressure and ameliorate cardiac hypertrophy via the downregulation of their indirect target TLR4 (153–155). Here, TLR4 is linked to hypertensive disorder.