Traditional Chinese Medicine drugs, such as Shenqi Yangxin decoction (SQYXD), Lycium barbarum polysaccharide (LBP), arbutin, Astragaloside IV (AsIV), and Dangshen Erling decoction (DSELD) have been shown to attenuate cardiac hypertrophy by targeting the high mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) and TLR4/NF-κB signaling pathway (146–150). The gene discussed is HMGB1; the disease is cardiac hypertrophy.