Other chemical compounds, such as Triad3A (a ubiquitin E3 ligase), TAK-242, and lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS), have been reported to negatively regulate the NF-κB activation pathway via the inhibition of TLR4/TLR9 or TLR4 and subsequently inhibit cardiac disease (124–127). Here, TLR4 is linked to heart disorder.