Lower total and HDL ApoE levels were significantly correlated with the presence of CSO-EPVS (absence = 55.61 ± 21.15 mg/L and 441.36 ± 267.94 μmol/mol chol vs. presence = 42.92 ± 14.48 mg/L and 306.72 ± 192.85 μmol/mol chol; p = 0.014, and p = 0.044, respectively) and with the corresponding degree score (p = 0.045 and p = 0.032, respectively) (Figure 4B). This evidence concerns the gene APOE and craniosynostosis.