Chemerin, a chemoattractant for macrophages and dendritic cells is also an adipokine and appears to contribute to insulin resistance.26 In a prospective study, chemerin predicted the onset of T2DM over a period of 5.3 years.27 IL-6 is considered both a cytokine and adipokine7,28 and correlated with HOMA-IR. The gene discussed is RARRES2; the disease is type 2 diabetes mellitus.