In M. oryzae, thus far, the only phytopathogen with an in-depth characterization of Sir2, this sirtuin controls virulence through deacetylation of the transcriptional repressor Jmjc, which allows the expression of the superoxide dismutase Sod1, with important roles in ROS detoxification during the first few steps of infection (Fernandez et al., 2014). This evidence concerns the gene SOD1 and infection.