Loss of cholinergic neurons and terminals in basal forebrain and cortex, respectively, as well as nAChR loss (see above) are prominent features of AD (Hellstrom-Lindahl and Court, 2000; Gotti et al., 2006b; Hoskin et al., 2019; Bekdash, 2021), especially of the early phase of the disease, and stimulation of cholinergic function using acetylcholine esterase inhibitors is an approved therapeutic strategy for AD. Here, ACHE is linked to Alzheimer disease.