Mean IgG S‐protein antibody fold‐change titres for unvaccinated infected women, those with previous history of two or more vaccination doses and those with two doses and evidence of infection were 10.29 (±5.08 standard deviation [SD]), 12.66 (±4.32 SD) and 15.05 (±4.37 SD), respectively. This evidence concerns the gene PROS1 and infection.