Abundant cytokines, transcription factors, and cell networks, such as inflammatory cytokines including interleukin (IL)-1, IL-6, IL-17, tumor necrosis factor-alpha (TNF-α) and immunocytes including T cells, B cells, and dendritic cells, participated in the crosstalk of signaling pathways underlying the pathogenesis of severe bone loss and osteoporosis [9]. This evidence concerns the gene TNF and osteoporosis.