HIVE score 1 or 2 and HIVE score 0 groups were similar in age, gender, race, duration of HIV infection, CD4 counts, and CSF VL, but individuals with HIVE score 1 or 2 had an increasing trend for plasma VL and significantly lower neurocognitive T-scores than those with HIVE score 0 (p = 0.08 and p = 0.007, respectively). Here, CD4 is linked to HIV infectious disease.