Untreated IC (n = 1014): HBV DNA < 2000 IU/mL and ALT ≤ 40 IU/mL (mean age 52 years, mean HBV DNA 102 IU/mL)vs. NA-treated (n = 1378): HBeAg positive, HBV DNA ≥20,000 IU/mL, ALT ≥ 2× ULN † or HBeAg negative, HBV DNA ≥2000 IU/mL, ALT ≥ 2× ULN † or compensated cirrhosis, HBV DNA ≥2000 IU/mL, any ALT or decompensated cirrhosis, any ALT (mean age 48 years, mean HBV DNA 106 IU/mL)NA-treated patients with HBV DNA < 2000 IU/mL during follow-up were classified as complete responders (CR; n = 1132). Here, GPT is linked to Cirrhosis.