CASP1 and infection: These data showed that JEV could stimulate the activation of NFκB upstream genes IRF3 and IRF7, and the upstream genes of interferon pathway RIG-1 and TLR7; the caspase family, such as caspase-1 and caspase-9; and other genes significantly increased after infection in normal cells, indicating that the inflammatory responses of cells did become stimulated after JEV infection.