The presence of IgG1 was associated with a positive diagnosis of COVID-19 (p = 0.021), IgG2 was associated with fever (p = 0.009) and chills (p = 0.025), IgG3 was associated with headache (p = 0.028), and IgG4 was associated with fever (p = 0.016), sore throat (p = 0.039), muscle pain (p = 0.010), chills (p = 0.004), sweating (p = 0.002), and hypertension (p = 0.018) (Figure 2). This evidence concerns the gene IGHG3 and COVID-19.