D: TDP43 proteinopathy: two elderly patients (88 and 86 years, case #1 and #26) showed pTDP-43 protein aggregates in the limbic system representing LATE (limbic age-related TDP43 encephalopathy), with neither hippocampal sclerosis nor signs of motor neuron disease or extensive fronto-temporal involvement. The gene discussed is TARDBP; the disease is motor neuron disorder.