A: Alzheimer’s disease neuropathological change: the combination of tau-positive neurofibrillary pathology and ßA4-amyloid/neuritic plaques +/− amyloid angiopathy was identified in 10 patients (32%) (Figure 3B1,B2), most of them aged over 70 years (mean 79, median 80, range 62–97) (cases #1,#3,#5,#10,#14, #17, #18, #26, #27, #28), but not in younger patients. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.