Cyclooxygenase-2 (COX-2), which is primarily responsible for prostaglandins produced in inflammatory sites, is reported to be upregulated in various cancer tissues and plays an important role in the disease progression of breast, colon, lung, and bladder cancers, as well as in prostate cancer [13,14,15,16,17]. The gene discussed is PTGS2; the disease is Familial prostate cancer.