Importantly, the ALI-differentiated FBTEC cultures express the SARS-CoV-2 entry receptor angiotensin converting enzyme II (ACE2) and entry factor transmembrane protease serine 2 (TMPRSS2) and are permissive to infection with multiple SARS-CoV-2 variants (Washington, Beta, Delta and Omicron). Here, ACE2 is linked to infection.