In fact, increased NF-κB levels were found in liver biopsies of HBeAg-negative patients compared to HBeAg-positive patients, and HBeAg-activation of macrophages via the TLR-2/NF-κB signal pathways, where HBeAg binds to the TLR2, has been found in patients with exacerbated hepatic fibrosis [87,93]. This evidence concerns the gene NFKB1 and Hepatic fibrosis.