When we again pre-treated ZAP KO and WT 293T cells with 5 U/mL IFN-β for 24 h before infection, we found a significant decrease in RRV production at 48 h post-infection (h.p.i.)in WT compared to the ZAP KO 293T cells (Figure 2A). The gene discussed is ZC3HAV1; the disease is infection.