We measured the levels of 13 cytokines, including IFN -α, IFN-γ, IL-4, IL-6, IL-10, CCL2, CCL3, CCL4, CXCL9, CXCL10, TNF-α, VEGF, and GM-CSF from both the sera and tumor samples from the B16 melanoma mice group (n = 3), which had the best response to the viral therapy in comparison with 4T1 breast cancer or CT26 colon carcinoma. This evidence concerns the gene IL4 and neoplasm.