IFNAR1 and infection: Alternatively, type I IFN signalling can be transiently suppressed in wild-type mice using the IFNAR1-blocking, non-cell-depleting monoclonal antibody MAR1-5A3 [37], which has been shown to render them susceptible to infection with low-passage clinical isolates of WNV [34], ZIKV [38,39,40], and DENV1 [41].