PMEL and neoplasm: Other CTAs such as GAGE, XAGE, BAGE and PAGE families, SSX1, SSX2 largely remain unexplored in many cancers, while targeting tumor-associated antigens such as MART-1, gp-100 with TCR T cell-directed therapy, also called tissue differentiation antigens, mediated tumor regression in 30% and 19% of patients, while at the same time targeting the normal tissues expressing cognate antigens in patients leads to off-target toxicity [37].