The neutralization activities of the NTD-targeting antibody SA3-hFc against wild-type (WT) and variant SARS-CoV-2 spikes were evaluated in a PSV infection assay and compared to S-E6-IgG4, which showed compatible potent neutralization against SARS-CoV-2 WT and variants in a dose-dependent manner. The gene discussed is STAG3; the disease is infection.