Instead of neutralizing the new serotype of DENV, these antibodies form complexes with DENV that bind to Fc gamma receptor (FcγR)-bearing myeloid cells, resulting in increased viral uptake and replication, leading to a potentially lethal dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) [18,19]. The gene discussed is FCGR2A; the disease is Dengue hemorrhagic fever.