Systemic inflammation can be also associated with fatigue, malaise, diarrhoea, laboratory abnormalities (raised C-reactive protein and erythrocyte sedimentation rate), and extracutaneous neutrophilic inflammatory involvement, including cholestasis, arthritis, interstitial pneumonia, oral lesions, and acute renal failure [1,2,3,4]. The gene discussed is CRP; the disease is arthritic joint disease.