The serum level and half–life of p53 protein is increased when there are mutations in the Tp53 gene, degradation of protein or viral cancer genes and as such it can be used for screening, prognosis or monitoring of many cancer types such as lung, head, neck, rectal, oral, prostate and some gynecological cancers such as breast and cervical cancers with high diagnostic performance [72]. The gene discussed is TP53; the disease is female reproductive organ cancer.