The first rectangular and tubular DNA origami structure was created, transfected into tumor cells for in vivo gene therapy, and silenced the mRNA of BCL-2 using short interfering RNA, according to M. A. Rahman et al. The results showed that 70% of BCL-2 mRNA was silenced, and up to 90% of BCL-2 was knocked out [80]. The gene discussed is BCL2; the disease is neoplasm.