BAK1 and melanoma: To this end, the expression profile of a selective panel of intrinsic and extrinsic apoptotic genes demonstrated a (i) ≥2-fold up-regulation in the expression of BAX, BAK, and BAD in addition to CASPASES -3 and -8, while it demonstrated a (ii) ≤0.5-fold down-regulation in the expression of FADD, TRADD, TNFRSF10A, and TNFRSF10C in both melanoma cell lines.