EGFR and malignant colon neoplasm: The study describes an N-acylhydrazone derivative of LASSBio-1586 [9], named LASSBio-1920, with potent in vitro cytotoxic activity, especially against HCT-116 cells (human colon cancer) and PC-9 cells (human lung cancer with overexpression of EGFR with L858R mutation).