TNF and Familial prostate cancer: This hypothesis is confirmed by the evidence that curcumin decreased proinflammatory cytokines and transcription factors (tumor necrosis factor, IL-6, NFkB, and VEGF) in multiple myeloma patients, as well as the tumor markers carcinoembryonic antigen and prostate-specific antigen in breast and prostate cancer patients, respectively [29,31,33].