Similar to PSMB5, Proteasome 20S subunit beta 8 (PSMB8) overexpression correlates with the progression of gastric cancer, its inhibition in glioblastoma increases apoptosis and decreases angiogenesis [39,40], and its mutation leads to inflammation and lipodystrophy [41]. The gene discussed is PSMB5; the disease is lipodystrophy.