Proteasomal subunits PSMB5 and PSMB8 are highly upregulated in chordoma cell lines U-CH1 and U-CH2: As we found, proteasomal inhibitors as one class of the hits from primary screening; next, we asked whether proteasomal subunits are increased in chordoma. The gene discussed is PSMB5; the disease is chordoma.