TNF and neoplasm: The highly metastatic tumor cells internalizing anti-TNF-α antisense oligonucleotide complexed with a cationic konjac glucomannan (cKGM) were used to generate small ABs (sABs); the complexed cKGM could mediate the internalization of the complex by the tumor cells via mannose receptors on the cell membranes (Figure 7A) [95].