PPM1D and neoplasm: Besides, the biomimetic macrophage-derived EVs were developed to deliver nanomedicine into the brain; the cRGD-modified exosome membranes were incorporated with the micelles that loaded with panobinostat and p53-induced protein phosphatase 1 (PPM1D) siRNA, and the composite system showed significant accumulation in the brain and targeting ability to tumor cells (Figure 6) [92].