As reported above, the ALKA-372-001, STARTRK-1, and STARTRK-2 studies evaluated both the safety and efficacy of orally administering entrectinib to adult patients with locally advanced metastatic cancer with NTRK1, NTRK2, NTRK3, ROS1, or ALK rearrangements. The gene discussed is ROS1; the disease is metastatic malignant neoplasm.