TNFRSF1A and rheumatoid arthritis: Wang et al. used ultrasound-targeted microbubble destruction (UTMD) for the transfection of TNFR plasmid, and the TNFR gene was observed to be continuously expressed in the rats for 8 weeks at least, which might alleviate RA symptoms and decrease the concentrations in the synovial tissues and peripheral blood [73].