Trisomy of chromosome 8 and monosomy of chromosome 7 are common alterations observed in MDS patients [69] and these cytogenetic features correlate with the upregulation of the oncogenes c-myc, Wilms Tumor 1 (WT1), and Cyclin D1, thus increasing the proliferation capacity of these cells [70]. The gene discussed is CCND1; the disease is myelodysplastic syndrome.