Moreover, THLG-EXO/miR-21i and THLG-EXO/5FU/miR-21i rescued the protein expression of hMSH2 and PTEN in the tumor tissue, but the singly administered 5FU via THLG-EXO had almost no detectable effect on the expression of hMSH2 and PTEN. Here, MSH2 is linked to neoplasm.