EGFR and glioblastoma: Some nanoparticles also have their own antivascular effects; for example, Zhang synthesized an H1/pHGFK1 nanoparticle as an angiogenesis inhibitor for GBM therapy; HGFK1 inhibits angiogenesis by regulating the EGFR and bFGF signaling pathways, increasing the resistance of glioblastoma cells to radiotherapy [133].