Ding developed a pH-lowering dual-reactive drug release system for the programmable release of CA4 and CDDP nanocarriers, which enables the release of CA4 at perivessel sites in tumor tissues to destroy blood vessels to be achieved; this cargo is absorbed by cancer cells inside the tumor tissue, and the reducing conditions surrounding cells trigger the release of CDDP and promote the apoptosis of cancer cells (Figure 3C) [70]. This evidence concerns the gene CA4 and cancer.