CD177 and human African trypanosomiasis: Because liposome-encapsulated pentamidine will enter the macrophage by endocytosis, and not through receptor-mediated uptake, this will reduce the likelihood of resistance evolution, as it has been shown for African trypanosomiasis, where pentamidine delivered in chitosan nanoparticles bypassed drug resistance mechanisms in the parasite associated to cell surface receptors [81].