While an increasingly wide array of signaling pathways have been found to play roles in the tumorigenesis of various cancers, the phosphoinositide 3-kinase (PI3K) pathway is heavily dysregulated in the majority of cancers, leading to elevated phosphatidylinositol 3,4,5-trisphosphate (PIP3) [3,4]. The gene discussed is PIK3CD; the disease is cancer.