A high level of ROR1 expression was noted to be associated with an aggressive and poor prognosis disease in, for example, CLL, DLBCL, MCL, ALL, as well as in ovarian, breast, pancreatic, gastric, colorectal, and lung cancers [15,18,21,32,59,60,61,62,63]. Here, ROR1 is linked to acute lymphoblastic leukemia.