ARI-1 ((R)-5,7-bis (methoxymethoxy)-2-(4-methoxyphenyl) chroman-4-one) is a novel ROR1 inhibitor targeting the external CRD domain of ROR1, preventing NSCLC cell proliferation, migration, as well as inactivating the PI3K/AKT/mTOR signaling pathway [42]. Here, MTOR is linked to non-small cell lung carcinoma.