A high level of ROR1 expression was noted to be associated with an aggressive and poor prognosis disease in, for example, CLL, DLBCL, MCL, ALL, as well as in ovarian, breast, pancreatic, gastric, colorectal, and lung cancers [15,18,21,32,59,60,61,62,63]. This evidence concerns the gene ROR1 and mantle cell lymphoma.