EGF and neoplasm: The presence of MDSCs may support the establishment of a suppressed immune environment at the tumor site, with fewer functional CD8+ T lymphocytes, and may support tumor growth in different ways, such as by producing angiogenesis factors, including transforming growth factor beta, platelet-derived growth factors (PDGRs), fibroblast growth factors (FGFs), and epidermal growth factors (EGFs) [81].