This is compounded by aspects related to the tumor microenvironment, including tumor-associated microglia/macrophages, secretion of protumorigenic/survival factors (IL-10 and IDO), vascular-related factors (VEGF, FGF, and pericyte proliferation), and release of immunosuppressive extracellular vesicles [36,38,39]. This evidence concerns the gene IL10 and neoplasm.