GDNF and wet macular degeneration: Other intravitreal drug delivery methods include the use of vitamin E/poly-lactic-co-glycolic acid microspheres containing glial cell line derived neurotrophic factor (GDNF) to protect retinal ganglion cells and biodegradable polyester amide implants for diabetic macular edema and neovascular age-related macular degeneration treatment [15,16,17].