In 1999, Supattapone and his group transfected a murine neuroblastoma cell line (N2a) with DNA coding for an epitope-tagged PrP using the transfection reagent SuperFectTM (Qiagen) to create a persistently PrPSc-infected murine neuroblastoma cell line (ScN2a). This evidence concerns the gene PRNP and neuroblastoma.