In a cohort of 105 individuals with very-early-onset coronary artery diseases (<35 years old), the occurrence of FH pathogenic mutations (including LDLR, APOB, PCSK9, APOE, STAP1, LIPA, LDLRAP1, ABCG5/8) was 38.1% [25]. The gene discussed is LDLR; the disease is coronary artery disorder.