Indeed, upon virus (including OV) infection, host cells produce/expose host factors termed DAMPs (damage-associated molecular patterns), here including adenosine triphosphate (ATP), cell-free nucleic acids, calreticulin, heat shock proteins (HSPs), type-I interferons (IFNs) α and β and high mobility group box 1 (HMGB1) protein, that are sensed by immune cells and lead to their priming and/or activation [5,6]. The gene discussed is HMGB1; the disease is infection.