Since this evasion mechanism is able to block both RLR-dependent (NDV infection or poly(I:C) transfection) and RLR-independent (parvovirus infection) IFN production, it appears to act at a step shared by several IFN-inducing pathways and one downstream of IRF3 and NFκB nuclear translocation. Here, NFKB1 is linked to Parvoviridae infectious disease.