The failure of the DAIR procedure has been related [32] to multiple factors such as host-related factors (rheumatoid arthritis, old age, male sex, chronic renal failure, liver cirrhosis, and chronic obstructive pulmonary disease); implant-related factors (fracture as indication for the original surgery, cemented implants); factors related to severity of the infection (high serological CRP, a high bacterial inoculum, presence of bacteremia); and finally, causative micro-organisms (S. aureus and Enterococci). The gene discussed is CRP; the disease is infection.