In contrast, higher expression of IL17REL was associated with improved prognosis in HPV-positive HNSCC patients, while higher expression of CSPG5, IL17RB, CCL25, NPPC and TG trended towards improved prognosis and ENHO trended towards poor prognosis in HPV-positive HNSCC patients (Figure 4B). This evidence concerns the gene IL17RB and head and neck squamous cell carcinoma.