Our results suggest that the expression of IL17RB may influence the anti-tumor functions of CD4 Tem, memory B, and activated NK cells, and IL17REL may influence the anti-tumor functions of CD8Tcm, memory B cells, M1 macrophages, and Helper T cells in HPV-positive HNSCC tumors. The gene discussed is CD4; the disease is head and neck squamous cell carcinoma.