Moreover, HNSCC patients with higher tumor expression of IL17REL combined with high expression of either the CD8 Tcm, memory B, M1 macrophages, or Helper T cell TS also had improved prognosis compared to those HNSCC patients with lower tumor expression of IL17RB and high expression of either CD8 Tcm, memory B, M1 macrophages or Helper T cell TS (Figure 6, bottom panel). The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.