CD4 and infection: The generation of cytokines in the DC-CD4+ T cell co-cultures’ supernatants was then evaluated and showed that LdCen−/− infected DC with CD4T cell had a considerable increase in IL-12 p40 (Figure 4B) and TNF-α (Figure 4C) along with a significant decrease in IL-10 (Figure 4D) production compared to LdWT infection under control siRNA or JSH-23 untreated condition.